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在患有中枢神经系统淋巴瘤的患者中发生轨道神经淋巴瘤
Tara Shooshani1, Michael Han2, Jeremiah P Tao2
1School of Medicine, University of California, Irvine, CA 92697, USA.
Diagnostics (Basel, Switzerland)
|March 28, 2025
概括
神经淋巴瘤 (NL) 是一种罕见的神经透癌症,可能涉及轨道和神经 (CNs). 这种情况突出显示了由于扩散性大B细胞淋巴瘤 (DLBCL) 的轨道上的二次NL,这表明眼腺是活检部位.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
背景情况:
- 神经淋巴瘤症 (NL) 是血液性恶性瘤的罕见并发症,涉及外围和神经.
- 非霍奇金淋巴瘤 (NHLs) 和急性白血病是NL的主要原因.
- NL可以呈现为原发性疾病或已知的恶性瘤复发/进展的继发性疾病.
研究的目的:
- 报告一个独特的二次神经淋巴瘤病例,涉及轨道和头骨神经.
- 为了说明中枢神经系统 (CNS) 淋巴瘤直接扩散到神经.
- 建议眼腺作为一个潜在的活检部位,怀疑在NL中涉及CNV.
主要方法:
- 一个74岁的女性患有主要中枢神经系统扩散性大B细胞淋巴瘤 (DLBCL) 的病例报告.
- 临床,放射学和组织病理学评估轨道和神经的参与.
- 直接DLBCL扩散到眼神经 (CN V分支) 的组织病理学确认.
主要成果:
- 该患者出现了影响左轨道和头骨神经II,III,V和VI的二次NL.
- 组织病理学证实中枢神经系统DLBCL直接延伸到神经.
- 催腺增强被归因于瘤透.
结论:
- 神经淋巴瘤症可以表现为中枢神经系统淋巴瘤的次要轨道.
- 眼神经是淋巴瘤传播到眼腺的潜在途径.
- 眼腺可以作为一个可访问的活检部位来诊断涉及CN V的NL.
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