非编码RNAs在调节农场动物脂肪沉积中的作用
Jingxuan Li1,2, Xueyan Zhao1,2, Yanping Wang1,2
1Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Animals : an open access journal from MDPI
|March 28, 2025
概括
非编码RNAs (ncRNAs) 是农场动物脂肪沉积的关键调节者,影响肉质. 对这些分子机制的进一步研究可以改善牲畜的特征.
科学领域:
- 动物科学动物科学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 脂肪沉积对于农场动物的能量代谢和肉质量至关重要.
- 这是一个复杂的过程,由许多基因和分子因素调节.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在调节脂肪沉积中的重要作用.
研究的目的:
- 要总结调节农场动物脂肪沉积的分子机制.
- 审查各种ncRNAs (miRNAs, lncRNAs, circRNAs) 在脂肪沉积中的作用.
- 确定该领域未来的研究方向.
主要方法:
- 文献综述和现有研究的综合.
- 专注于转录因子,调节基因和信号通路.
- 对猪,牛,绵羊,和的ncRNA功能进行分析.
主要成果:
- ncRNAs关键调节各种农场动物的脂肪沉积过程.
- 特定的ncRNA如miRNAs,lncRNAs和circRNAs都参与其中.
- 了解这些途径为改善肉质特征提供了潜力.
结论:
- 在脂肪沉积的分子调节中,ncRNAs是关键的.
- 向ncRNAs有望提高畜牧业的肉质.
- 需要进一步调查才能充分阐明这些复杂的监管网络.
相关概念视频
Types of RNA
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Transcriptional Regulation: Riboswitches
Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
Translational Regulation
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...


