评估患有青春期异常性关节炎的儿童的肺功能:一个横截面研究
Şeyda Doğantan1, Sema Nur Taşkın2, Cansu Yılmaz Yeğit3
1Department of Pediatric Rheumatology, Başakşehir Çam and Sakura City Hospital, 34480 İstanbul, Türkiye.
Children (Basel, Switzerland)
|March 28, 2025
概括
患有青少年异常性关节炎 (JIA) 的儿童显示出较低的峰值呼气流 (PEF),但与对照组的整体肺功能相似. 建议对JIA患者进行定期的呼吸系统监测,以早期发现潜在的肺部并发症.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 青少年异常性关节炎 (JIA) 是一种慢性自身免疫性疾病,影响儿童,可能导致包括肺部参与在内的全身并发症.
- 在JIA中,关节炎可能会影响整体健康,并可能与呼吸系统问题有关.
- 早期识别肺部干扰对于全面的JIA管理至关重要.
研究的目的:
- 评估和比较JIA诊断的儿科患者的肺功能,与健康的对照组进行对比.
- 为了确定与儿童中JIA相关的特定呼吸道异常或指标.
- 在JIA中评估疾病活动和肺功能参数之间的关系.
主要方法:
- 一项前性横截面研究,涉及70名患有JIA的儿童和60名健康对照 (6-17岁).
- 使用螺旋计评估肺功能,测量强迫生命能力 (FVC),1秒强迫呼气体积 (FEV1) 和峰值呼气流量 (PEF).
- 还测量了氧和度 (SpO2),并考虑了疾病活性.
主要成果:
- 与对照组相比,JIA组的峰值呼气流 (PEF) 显著较低 (p=0.005).
- 与活性较低的儿童相比,中度至高JIA疾病活性的儿童显著减少FVC,FEV1和FEF25-75 (p<0.001).
- 与肠炎相关的关节炎亚型显示出更高的FVC和FEV1;FVC和FEV1与BMI正相关.
结论:
- 虽然在患有JIA的儿童中PEF较低,但在JIA患者和对照人群中,整体螺旋计肺功能在很大程度上是可比的.
- 这些发现强调了定期对患有JIA的儿童进行肺部监测的重要性,以早期发现和管理呼吸道并发症.
- 肺功能可能会受到疾病活动和特定的JIA亚型的影响.
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