自闭症谱系障碍,口腔影响和口腔微生物群
Emiliana D'Angelo1, Fausto Fiori1, Giuseppe A Ferraro2
1Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.
Children (Basel, Switzerland)
|March 28, 2025
概括
自闭症谱系障碍 (ASD) 与口腔和肠道微生物群失衡有关,影响行为和健康. 解决口腔健康和微生物群的问题可能会改善ASD并发症.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发育儿科 发育儿科
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,具有复杂的行为和社会挑战.
- 新兴研究强调了ASD和口腔和肠道微生物群中的失生症之间的重要联系.
- 本综述侧重于口腔微生物群,自我伤害行为 (SIB),感官敏感性和ASD并发症中的饮食之间的相互作用.
研究的目的:
- 检查口腔微生物群,SIB,感官敏感性和饮食习惯对ASD并发症的影响.
- 综合目前关于口腔健康,微生物群和ASD之间的关系的证据.
- 探索在ASD管理中针对微生物群和口腔健康的潜在治疗干预措施.
主要方法:
- 使用PubMed和Scopus数据库进行了广泛的文献审查.
- 专注于全文可用的人类研究,使用与ASD,口腔健康和微生物群相关的关键词.
- 对微生物群-口腔健康-ASD联系的方法质量和相关性进行评估的研究.
主要成果:
- 患有ASD的个体由于SIB和感官敏感性而经历了独特的口腔健康问题,复杂化了卫生.
- 自闭症患者的选择性饮食模式可能导致营养缺乏,并加剧口腔健康问题.
- 口腔和肠道微生物群失调,与改变的短链脂肪酸,破坏肠-大脑和口腔-大脑轴,恶化ASD症状.
结论:
- 在ASD,口腔健康和微生物群之间存在双向关系,由神经炎症和代谢障碍介导.
- 针对微生物群和牙健康的积极策略在减少自闭症并发症和改善整体管理方面表现有前途.
- 对微生物群与宿主相互作用的进一步研究对于理解和利用ASD治疗潜力至关重要.
相关概念视频
01:19Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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01:27The Oral Microbiota
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01:28Development of the Oral Microbiota
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01:22Gut-Brain Axis
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01:21Microbiota Modulation by Antibiotics
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