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Updated: May 2, 2026

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

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甲可不可逆地改变活细胞中的埋藏和暴露的氨酸残留物

Huan Ling1,2, Lin Li1, Liping Duan3

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Road, Shanghai 200032, China.

Journal of the American Chemical Society
|March 28, 2025
PubMed
概括

一种新的 lysine 生物结合化学物质 O-cyanobenzaldehyde (CNBA) 能够对 lysine 残留物进行选择性修饰. 这种方法可以绘制成千上万个 lysines 和 kinases 的地图,并开发有针对性的共价药物和抗体-药物结合物.

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