水素素作为膜蛋白:当前的状态
Irena Roterman1, Katarzyna Stapor2, Dawid Dułak3
1Department of Bioinformatics and Telemedicine, Jagiellonian University-Medical College, 30-688 Krakow, Medyczna 7, Poland.
Frontiers in bioscience (Scholar edition)
|March 28, 2025
概括
人类水族素具有结构上的相似性,适应稳定疏水环境,同时运输极性分子. 模糊油滴修改模型量化评估这种适应生物功能.
科学领域:
- 生物化学 生物化学
- 结构生物学 结构生物学
- 分子生物物理学 分子生物物理学
背景情况:
- 蛋白质折叠活动至关重要,并且取决于环境条件.
- 疏水性环境,如细胞膜,影响蛋白质的结构和功能.
- 水蛋白是对水和小分子运输至关重要的跨膜蛋白质.
研究的目的:
- 分析水的结构适应.
- 使用模糊油滴修饰 (FOD-M) 模型量化评估蛋白质结构适应环境条件.
主要方法:
- 使用修改后的模糊油滴 (FOD-M) 模型进行定量分析.
- 评估蛋白质结构适应生物活动相关的外部条件.
主要成果:
- 水蛋白具有稳定疏水环境的结构适应性.
- 这些蛋白质适应于极性分子的运输.
结论:
- 人类水族蛋白具有显著的结构相似性.
- 该FOD-M模型有效地量化了水族素对其生物功能和特定环境的适应性.
相关概念视频
Membrane Proteins
29.2K
Plasma membranes have integral transmembrane proteins involved in facilitated transport. These proteins are collectively referred to as transport proteins, and they function as either channels for the material or as carriers themselves. Channel proteins have hydrophilic domains exposed to the intracellular and extracellular fluids and a hydrophilic channel through their core that provides a hydrated opening for solutes to pass through the membrane layers. Passage through the channel allows...
29.2K
Single-pass Transmembrane Proteins
6.4K
Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
6.4K
The Significance of Membrane Transport
40.9K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
40.9K
Aquaporins
6.1K
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
6.1K
ATP Driven Pumps III: V-type Pumps
4.6K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
4.6K
Reabsorption and Secretion in the DCT and Collecting Duct
2.9K
The early phase of the DCT manages the reabsorption of approximately 10-15% of filtered water, 5–10% of filtered sodium, and 5–10% of filtered chloride. This process is facilitated by Na+–Cl− symporters in apical membranes and sodium-potassium pumps, as well as Cl− leakage channels in basolateral membranes. The early DCT also stands out as a site where parathyroid hormone (PTH) stimulates calcium reabsorption, depending on the body's requirements.
The distal...
The distal...
2.9K


