3D瘤模型中的瘤微环境的生物工程方面:对细胞,生物物理和生物化学相互作用的洞察
Salma T Rafik1,2, Deniz Bakkalci1, Alexander J MacRobert1
1UCL Centre for 3D Models of Health and Disease, UCL Division of Surgery and Interventional Science, Faculty of Medical Sciences, Charles Bell House, University College London, UK.
FEBS open bio
|March 28, 2025
概括
先进的3D体外模型为研究复杂的瘤微环境及其在癌症进展和转移中的作用提供了新的途径. 这些复杂的工具帮助研究人员更好地了解癌症.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 癌症生物学 癌症生物学
背景情况:
- 癌症的进展涉及瘤微环境 (TME) 内的复杂相互作用,超越遗传因素.
- TME包括动态的生物物理设置和癌症和非癌症细胞之间的相互作用.
- 了解TME组件的多面性质和相互依赖性对于癌症研究至关重要.
研究的目的:
- 审查最近瘤微环境的3D体外模型的进展.
- 讨论用于分析这些复杂模型的工具.
- 突出这些模型在阐明TME相互作用及其对癌症的影响方面的潜力.
主要方法:
- 利用组织工程原理创建3D体外模型.
- 开发和使用先进的分析工具来描述TME.
- 专注于患者特定的模型来复制瘤复杂性.
主要成果:
- 3D体外模型为研究TME复杂性和细胞相互作用提供了一个平台.
- 这些模型有助于研究TME对癌症进展和转移的影响.
- 最新的进展使得TME的多方面的组件能够进行详细的分析.
结论:
- 复杂的3D体外模型对于了解瘤微环境至关重要.
- 这些模型提供了关于癌症进展和转移的见解,这是癌症死亡的主要原因.
- 先进的分析工具提高了TME相互作用的阐明,以改善癌症研究.
相关概念视频
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...