血管内血栓切除术后的帕伦基马性血液瘤与预治疗相关 基底性瘤 心脏病发作 体积
Robert W Regenhardt1,2, Penina P Krieger1, Anna K Bonkhoff1
1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
概括
预防干预基底脉梗塞的体积与内血管血栓切除术后的辅酶血瘤有关. 这一发现可能有助于指导患者的治疗和未来对中风的神经保护策略.
科学领域:
- 神经学 神经学
- 干预性神经辐射学
- 脑卒中医学 脑卒中医学
背景情况:
- 帕伦基马性血液瘤 (PHs) 是因缺血性中风的内血管血栓切除术 (EVT) 后的一个重要并发症.
- 了解PH的风险因素对于改善患者的治疗结果至关重要.
- 预防干预神经成像,特别是心脏病发作地形,可以提供预测性见解.
研究的目的:
- 调查预防干预心脏病发作地形和EVT后PHs的发生之间的关联.
- 确定缺血性病变的特定地形特征,这些特征使患者易患PHs.
主要方法:
- 对接受EVT和EVT前MRI的大血管封闭患者的回顾性分析.
- 扩散权重成像 (DWI) 病变的手动细分和地形绘制.
- 对心脏病发作位置/体积和EVT后PH之间的关联进行统计评估.
主要成果:
- 在165名患者中,8%的患者在EVT后发展出PH.
- 预防干预病变主要发生在白质 (48%),皮质 (23%) 和基底腺 (15%) 中.
- 增加的基底脉梗塞体积独立地与更高的PH风险相关 (aOR=1.342,p=0.049).
结论:
- 预防干预基底脉梗塞的体积是EVT后PH发展的重要预测因素.
- 这一发现对完善患者在EVT期间的选择和管理有影响.
- 进一步研究基底梗塞的生物学可能会产生新的神经保护性点.
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