对于老年人来说,潜在不合适的药物清单:对发展应用的方法的审查
Omar Ammous1, Dawid Pieper2,3, Petra Thürmann4
1Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Lower Saxony, Germany.
Age and ageing
|March 28, 2025
概括
为老年人制定潜在不合适药物 (PIM) 清单缺乏标准化. 本次审查强调了PIM列表创建方法的显著变化,强调需要一个共识方法来提高患者安全.
科学领域:
- 老年人药理学 老年人药理学
- 医疗保健服务研究 医疗服务研究
- 药物安全 药物安全
背景情况:
- 不适当的处方 (IP) 是一个日益严重的公共卫生问题,特别是在全球人口老龄化和与年龄有关的疾病增加.
- 潜在不合适药物 (PIM) 清单是为减轻老年人IP问题而开发的关键工具.
研究的目的:
- 系统地比较用于开发老年人PIM列表的各种方法.
- 在PIM列表创建过程中识别共同点和差异.
主要方法:
- 对从1990年起出版的PIM列表进行了对MEDLINE和参考列表的全面文献搜索.
- 数据提取由两名审查员进行,第二名审查员验证了20%的提取信息.
- 通过叙事分析确定和综合了关键的开发方法.
主要成果:
- 包括31个PIM列表,包括新列表,更新,调整和扩展,重点关注特定地区或条件.
- 对老年人群的定义各不相同 (≥65至≥75岁),并使用多种来源来确定符合条件的药物,PubMed是最常见的.
- 虽然德尔菲方法经常用于达成共识,但在组织草案,小组选择,共识值和最终列表呈现方面存在重大差异.
结论:
- 在PIM列表开发方法的实质性变化强调了建立一个标准化,共识驱动的方法的关键需要.
- 标准化对于提高PIM清单在临床实践和公共卫生倡议中的可靠性和适用性至关重要.
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