酒精和衰老:下一代表观遗传钟预测了酒精使用障碍患者的生物衰老加速
Tyler A Perlstein1, Jeesun Jung1, Alexandra C Wagner1
1Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Alcohol, clinical & experimental research
|March 28, 2025
概括
格林时代的表观遗传钟,特别是第2版本,显示出与酒精使用障碍 (AUD) 和饮酒行为有很强的关联. 较新的因果关系丰富的时钟没有与AUD有显著的联系,但可以了解衰老的复杂性.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 成 药物 药物 药物 药物
背景情况:
- 长期大量饮酒会加速衰老,增加与年龄相关的疾病.
- 基于DNA甲基化 (DNAm) 的表观遗传钟预测生物年龄.
- 富含因果关系的表观遗传时钟是新的,但在酒精消费环境中尚未评估.
研究的目的:
- 评估酒精消费,酒精使用障碍 (AUD) 和新型表观遗传钟之间的关联.
- 为了比较 GrimAge 版本 1 (V1) 和版本 2 (V2) 与因果关系丰富的时钟 (CausAge, DamAge, AdaptAge) 相对于 AUD 的性能.
主要方法:
- 在615个人 (372名AUD患者,243名对照人) 中评估了表观遗传衰老,使用GrimAge V1,GrimAge V2,CausAge,DamAge和AdaptAge.
- 对AUD诊断,性别,种族,BMI,吸烟状况和血细胞类型进行控制的线性模型.
- 测试了酒精指标和年龄调整后的表观遗传钟之间的关联.
主要成果:
- GrimAge V1和V2在各个年龄组中始终与AUD和饮酒指标相关.
- GrimAge V2 总体上表现优于 GrimAge V1,特别是在肝功能酶和C反应蛋白方面.
- 富含因果关系的时钟显示了与AUD的有限显著关联,尽管DamAge与年轻人饮酒数量有关.
结论:
- 在评估酒精对生物衰老的影响方面,GrimAge V2表现比GrimAge V1有所改善.
- 富含因果关系的时钟需要进一步研究,以了解它们在酒精使用障碍和衰老动态中的作用.
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