心脏代谢并发症和癌症成年人死亡率之间的关联:跨国队列研究
Veronica Davila-Batista1,2,3, Vivian Viallon1, Emma Fontvieille1
1International Agency for Research on Cancer (IARC-WHO), Lyon, France.
BMJ medicine
|March 28, 2025
概括
在癌症患者中,先前存在的2型糖尿病或心血管疾病显著增加了全因和癌症特定死亡率的风险. 这些心脏代谢状况使癌症预后恶化,突出显示了综合护理的必要性.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 心脏代谢并发症在癌症患者中很普遍.
- 这些疾病对癌症死亡率的影响需要进一步研究.
研究的目的:
- 检查先前存在的心脏代谢并发症和癌症成年人死亡率之间的关联.
- 研究2型糖尿病和心血管疾病对癌症预后的单独和联合影响.
主要方法:
- 多国队列研究涉及来自七个欧洲国家的26,987名参与者 (EPIC研究).
- 利用多变量考克斯回归模型来估计死亡风险比率.
- 分析了由癌症存活率和常见癌症类型分层的关联.
主要成果:
- 以前存在的2型糖尿病,心血管疾病或两者都与全因和癌症特定死亡率的增加有关.
- 所有原因死亡率的风险比分分别为1.25,1.30和1.60对于糖尿病,心血管疾病和两者.
- 对于癌症,存活率较高 (≥80%) 的癌症,相关性更强.
结论:
- 心血管疾病和2型糖尿病,单独或联合,与癌症患者的死亡率更高有关.
- 这些发现表明,心脏代谢并发症在影响癌症预后方面起着直接作用.
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