概括
日本食品安全委员会重新评估了杀菌剂ferimzone,确定每日可接受摄入量 (ADI) 为0.019 mg/kg bw/day和急性参考剂量 (ARfD) 为0.3 mg/kg bw. 费里姆没有显示出遗传毒性或致病性.
科学领域:
- 食品安全 食品安全
- 毒理学 毒理学 毒理学
- 农业化学 农业化学
背景情况:
- 日本食品安全委员会 (FSCJ) 进行了对胺基酸杀菌剂ferimzone的风险评估.
- 根据农业化学品监管法要求重新评估,农业,林业和渔业部提交了额外的数据.
- 数据包括农作物和牲畜中的残留物,环境命运和科学文献.
研究的目的:
- 对杀菌剂ferimzone进行风险评估和重新评估.
- 为了确定食品中费里姆残留物的安全性.
- 为了确定ferimzone的可接受每日摄入量 (ADI) 和急性参考剂量 (ARfD) 值.
主要方法:
- 审查提交的文件和科学文献.
- 对米,牛和的残留物数据的分析.
- 对老鼠,小鼠和狗的毒理学研究的评估,包括慢性毒性,致癌性和基因毒性评估.
主要成果:
- 在毒理学研究中,费里姆主要影响肝脏和血液 (贫血).
- 没有观察到对生育能力,产性或基因毒性的不良影响.
- 最低的无观察不良影响水平 (NOAEL) 是1.94 mg/kg bw/day (慢性毒性/致癌性在老鼠中).
结论:
- 使用100的安全系数确定了0.019 mg/kg bw/day的可接受每日摄入量 (ADI).
- 使用100的安全系数,确定了0.3 mg/kg体重的急性参考剂量 (ARfD).
- 在确定的摄入水平下,费里姆被认为是安全的,已确定目标器官是肝脏和血液.
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