概括
日本食品安全委员会确定了食品中 perfluorooctane sulfonate (PFOS) 和 perfluorooctanoic acid (PFOA) 的每日可容忍摄入量. 虽然数据存在不确定性,但这些PFAS化合物的日均摄入量低于确定的限值.
科学领域:
- 食品安全和毒理学
- 环境化学环境化学
- 风险评估 风险评估 风险评估
背景情况:
- 和多醇基物质 (PFAS) 是广泛使用的化学物质,具有潜在的健康问题.
- 国际和国家机构越来越多地评估食品中的PFAS风险.
- PFOS,PFOA和PFHxS是监管利益的主要PFAS化合物.
研究的目的:
- 为了进行食品中PFAS的风险评估.
- 为了确定关键的PFAS化合物的可容忍每日摄入量 (TDI) 水平.
- 将估计的饮食摄入量与已确定的TDI进行比较.
主要方法:
- 审查了来自国际机构和国家机构的科学文献和风险评估.
- 调查了关于PFOS,PFOA和PFHxS的科学发现.
- 从使用人类等效剂量 (HED) 转换模型的动物研究中获得参考剂量.
- 分析了日本总饮食研究 (2012-2014) 的平均每日摄入量数据.
主要成果:
- 对于PFOS的确定的TDI为20 ng/kg体重/天.
- 对于PFOA的确定的TDI为20 ng/kg体重/天.
- 由于数据不足,无法确定PFHxS的参考剂量.
- 在日本,PFOS (0.60-1.1 ng/kg/day) 和PFOA (0.066-0.75 ng/kg/day) 的平均每日摄入量低于TDI.
- 摄入量估计存在重大不确定性,原因是各种食品中PFAS度数据有限.
结论:
- 已经为PFOS和PFOA设定了TDI,这表明日本目前的平均摄入水平低于这些值.
- 需要进一步的研究来解决有关PFAS度和食品中的分布的数据缺口,以完善风险评估.
- 该评估强调需要对PFAS暴露和安全进行持续的监测和研究.
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