血清费里丁与生活在高海拔地区的普通人群中的异位性脂质特征相关
Menglong Jin1, Mawusumu Mamute2, Hebali Shapaermaimaiti3
1Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
PeerJ
|March 28, 2025
概括
血清费里丁 (SF) 水平与高海拔居民的不健康脂质样本有关. 这种关联,特别是与甘油三,即使SF不被认为是炎症标志物,仍然存在.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 高海拔地区的生理学
背景情况:
- 血清费里丁 (SF) 与代谢综合征和脂质不良症有关.
- 在高海拔地区的人群中,SF和动脉动脉性脂质样本之间的关系尚不清楚.
研究的目的:
- 为了研究血清费里水平与生活在高海拔地区的塔吉克成年人血清费里水平和血清脂肪蛋白质的相关性.
- 根据性别和炎症标志物,探索这种关联中的潜在差异.
主要方法:
- 一项对1,703名居住在平均海拔3100米的塔吉克成年人的横截面研究.
- 收集人口统计,人体测量和禁食血液样本进行生物化学分析.
- 使用单变量线性回归,逻辑回归和子组分析来评估SF和脂质资料之间的关联.
主要成果:
- SF水平与总胆固醇,LDL-C,HDL-C,甘油三 (TG) 和小密度的LDL-C (sdLDL-C) 有显著的相关性,但不是脂蛋白 (a).
- 在男性和女性中,高的SF与失脂症有关,特别是高的TG.
- 在调整了混因素后,SF在两种性别中仍然与高TG有显著的相关性.
结论:
- 血清费里丁与高海拔群体中的异位性脂质配置,特别是甘油三,密切相关.
- 观察到的SF和脂质配置文件之间的关联与SF作为炎症标记物的作用是独立的.
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