睡眠障碍是动脉缩的危险因素之一
Nadim El Jamal1,2, Thomas G Brooks1,2, Carsten Skarke1,2
1Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA, USA.
American journal of preventive cardiology
|March 28, 2025
概括
睡眠障碍增加了大动脉狭窄 (AS) 发生的风险. 脂质特征的变化部分解释了这种关联,突出显示了睡眠健康和膜心脏病之间的联系.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 循环节律障碍和睡眠障碍与心血管疾病有关.
- 睡眠障碍与膜心脏病,特别是大动脉狭窄症 (AS) 之间的具体关系尚不清楚.
- 电子健康记录 (EHR) 为调查这些关联提供了宝贵的资源.
研究的目的:
- 调查睡眠障碍与未来大动脉狭窄症 (AS) 发生率之间的联系.
- 探索潜在的生化机制,如脂质配置文件,这是这种关联的基础.
主要方法:
- 利用了两个大型电子健康记录 (EHR) 数据集:TrinetX网络和我们所有人的研究.
- 采用Cox比例危险模型来评估睡眠障碍患者中AS发病率的风险.
- 对临床实验室测试数据进行调解分析,以确定涉及的生物化学因素.
主要成果:
- 发现任何睡眠障碍都会显著增加未来AS发病率的风险 (HR:1.15,95% CI:1.13-1.18).
- 脂质配置文件的变化被确定为睡眠障碍和AS之间的关联的显著调解者.
- 观察到的关联即使在调整了经典心血管风险因素后,也仍然显著.
结论:
- 睡眠障碍独立地与大动脉狭窄发病率增加的风险有关.
- 失脂症在调解睡眠障碍与AS之间的联系方面发挥着重要作用.
- 这些发现强调了在心血管疾病预防策略中解决睡眠健康问题的重要性.
更多相关视频
相关概念视频
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...


