通过电荷切换方法在黄素和蛋白质之间进行纳米复杂化,以改善黄素的物理化学和生物特性
Anyu Zhang1, Manish Mahotra1, Hong Yu1
1School of Materials Science and Engineering, Nanyang Technological University 50 Nanyang Avenue 639798 Singapore joachimloo@ntu.edu.sg.
RSC advances
|March 28, 2025
概括
黄素-蛋白质纳米复合物显著增强黄素的作用.
科学领域:
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
- 材料科学 材料科学 材料科学
背景情况:
- 黄素表现出抗氧化和抗微生物特性,但其水溶性较差.
- 低水溶性限制了黄素在各种应用中的生物可用性和有效性.
研究的目的:
- 开发使用牛血清白蛋白 (BSA) 和凝的素蛋白纳米复合物.
- 为了提高黄素的可溶性,生物可访问性和抗菌活性.
主要方法:
- 采用电荷交换方法,通过混合相反电荷的黄素和蛋白质,形成纳米复合体.
- 评估了溶解度,载荷能力,生物可访问性和抗菌活性.
主要成果:
- 与BSA和凝的复杂化增加了黄素的溶解度和加载量.
- 观察到增强的生物可访问性,抗氧化剂和抗微生物特性.
- 针对食物传播病原体的最小抑制度 (MIC) 显著降低,例如Vibrio和Bacillus物种.
结论:
- 黄素-蛋白质纳米复合物为克服黄素的可溶性限制提供了一个有希望的策略.
- 这些纳米复合物可以作为有效的非抗生素添加剂,用于农业食品部门的微生物疾病管理.
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