过敏疾病与支气管病变之间的关联的调解者:双向单变量和多变量门德尔随机化研究和调解分析
Ping-An Zhang1, Jie-Lin Wang2, Shi-Yan Fu1
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, 151, Yanjiangxi Rd, Guangzhou, Guangdong, 510120, China.
过敏性喘,鼻炎,结膜炎和皮肤炎会增加支气管切开的风险. 三种代谢比率调解了这种联系,突出了过敏和肺部健康之间的复杂相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 支气管切除症经常与过敏状况同时发生.
- 复杂的发病过程涉及免疫反应,新陈代谢和肠道微生物群.
- 支气管切除和过敏之间的因果关系需要进一步阐明.
研究的目的:
- 调查五种过敏疾病与支气管病变之间的因果关系.
- 确定这种关系中的遗传关联和调解因素.
- 探索免疫细胞,蛋白质,代谢物和肠道微生物群的作用.
主要方法:
- 使用双向双样本的门德尔随机化 (TSMR) 对过敏性疾病和支气管切除的GWAS数据.
- 用于基因相关性分析的雇员联系不平衡得分回归 (LDSC).
- 应用了两步TSMR和多变量MR来评估免疫细胞,蛋白质,代谢物和肠道微生物群的调解.
主要成果:
- 发现过敏性喘,鼻炎,结膜炎和皮肤炎会增加支气管切开症的风险.
- 没有观察到气管支气管和过敏性疾病之间的反向因果关系.
- 确定了40个免疫细胞,5个炎症蛋白,90个代谢物和19个肠道微生物群作为因果因素.
- 特定的代谢比率 (瑞醇/甘油,阿斯巴达酸/N-乙烯基葡萄糖胺/N-乙烯基葡萄糖胺,甲胺/酸盐) 调解了过敏和支气管切除症之间的联系.
结论:
- 过敏性疾病是发展支气管病的重要危险因素.
- 三种不同的代谢比率在过敏-支气管炎路径中起到关键的调解作用.
- 进一步的研究是必要的,以充分了解潜在的生物机制.
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