选择性色素再吸收抑制剂 (SSRI) 和手术出血在整形外科:一个系统的审查
Nathan John1, Francisco A Ferri2, Emanuella M Brito3
1General Surgery, Cleveland Clinic Florida, Weston, USA.
Cureus
|March 28, 2025
概括
选择性血红素再吸收抑制剂 (SSRI) 增加了整形手术中的出血风险,特别是乳腺手术中的血瘤再手术. 由于数据有限,需要对面部手术进行进一步研究.
科学领域:
- 整形和重建手术 整形和重建手术
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是广泛用于精神疾病的药物.
- 通过影响血小板聚合,SSRI可能会损害血静,从而可能增加出血风险.
- 在塑料和重建手术 (PRS) 中使用SSRI的临床影响需要仔细考虑,因为出血风险与停药综合征相比.
研究的目的:
- 系统地审查有关SSRI消费与在整形和重建手术中出血结果之间的相关性文献.
- 在使用SSRI的患者中评估软组织手术中出血并发症的风险.
主要方法:
- 使用国家生物技术信息中心 (NCBI) 和Embase数据库进行了系统审查.
- 确定了在PRS和软组织手术中调查SSRI使用和出血结果的出版物.
- 包括五项回顾性队列研究,尽管研究设计和结果的异质性阻止了元分析.
主要成果:
- 总体而言,手术后出血率在1.9%至2.6%之间.
- 研究表明,在接受SSRI的患者中,乳腺化品 (OR 4.14) 和瘤 (OR 2.7) 程序的血液瘤再手术的风险增加.
- 在两项低功率研究中,没有发现面部手术的出血事件显著增加,而一项研究发现没有增加输血风险.
结论:
- 乳腺和面部PRS显著出血并发症的风险似乎很低,SSRI使用与乳腺手术中血再手术增加不到5%有关.
- 目前关于面部整形外科手术中SSRI相关出血的证据受研究质量限制,通常依赖病例报告.
- 需要进一步的高层次研究,特别是面部,四肢和手术,以充分阐明SSRI相关的出血风险.
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