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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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相关实验视频

Updated: May 10, 2026

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

在固体癌症中绘制MAGE-A4表达的地图,用于向治疗.

Christin Habigt1, Sylvie Rottey2, Iben Spanggaard3

  • 1Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Munich, Penzberg, Germany.

Frontiers in oncology
|March 28, 2025
PubMed
概括

黑色素瘤相关抗原A4 (MAGE-A4) 蛋白在35%的实体瘤中表达. 高MAGE-A4表达在腺体囊性癌,脂肉瘤和卵巢癌中被发现,表明潜在的治疗点.

关键词:
生物标志物生物标志物临床试验临床试验临床试验临床试验临床试验患者的选择患者的选择目标表达式是目标表达式.翻译分析是一种翻译分析.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

相关实验视频

Last Updated: May 10, 2026

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 黑色素瘤相关抗原A4 (MAGE-A4) 是癌症免疫治疗的潜在目标.
  • 关于MAGE-A4蛋白在各种固体瘤中的表达存在有限的数据.

研究的目的:

  • 在各种固体癌症中全面评估MAGE-A4蛋白表达.
  • 为针对性抗MAGE-A4疗法确定高MAGE-A4流行率的癌症类型.

主要方法:

  • 免疫组织化学 (IHC) 用于分析MAGE-A4蛋白表达.
  • 检查了200名患有无法切除/转移的固体癌症患者的样本.
  • 该队列主要是HLA-A*02:01阳性.

主要成果:

  • 在整体队列的35% (69/200名患者) 中检测到MAGE-A4表达.
  • 在腺体囊性癌 (82%) 和脂质肉瘤 (67%) 中观察到的MAGE-A4发病率最高.
  • 在卵巢血清/高度癌症 (64%),状非小细胞肺癌 (64%),头状细胞癌 (60%) 和食道癌 (54%) 中也发现了显著的积极性.

结论:

  • 在不同类型的癌症中,MAGE-A4的表达有很大差异.
  • 特定的癌症显示MAGE-A4的高患病率,这表明了分层精确医学方法的潜力.
  • 对MAGE-A4在瘤发生和治疗反应中的作用进行进一步研究是有必要的.