男人青春期时间对外化和内化特征的发展的因果作用:来自孟德尔随机化研究的结果

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Lars Dinkelbach^1,2, Triinu Peters^2,3,4, Corinna Grasemann⁵

¹Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Psychological medicine

|March 28, 2025

概括

这项研究使用了门德尔的随机化来研究男性青春期时间 (MPT) 和行为特征之间的因果关系. 早期的MPT与早期的性接触和抑郁情绪等外部化行为有因果关系,但不是长期的临床疾病.

科学领域:

行为遗传学行为遗传学
精神病学是一个精神病学.
流行病学流行病学

背景情况:

观察性研究表明,早期男性青春期与外部化/内部化行为之间存在联系.
由于观察研究中的混,因果关系仍然不确定.
门德尔随机化 (MR) 提供了一种使用遗传变异建立因果关系的方法.

研究的目的:

调查男性青春期时间 (MPT) 对外化和内化特征和精神病理的因果关系.
区分MPT的直接影响与由相关行为介导的直接影响.
评估MPT的长期临床影响.

主要方法:

利用来自大型全基因组关联研究 (GWAS) 的76个独立的MPT遗传变异.
雇佣了MR来分析MPT遗传变异和17个外部化/内部化特征之间的关联.
对结果变量 (16,400-1,045,957名参与者) 的大规模GWAS数据进行了杆化.

主要成果:

早期的MPT显示与"外部化特征"表型的因果关系,主要是由第一次性接触时的早期年龄驱动的.
没有证据支持MPT对其他外部化表型的因果作用.
早些时候的MPT与更高的'抑郁影响' (神经病症子域) 有关.
后来MPT与早期生活中增加的内化特征有关.

结论:

这项MR研究提供了男性青春期时间对特定行为特征的因果关系的证据.
在MPT和长期临床结果 (如抑郁症,焦虑症或药物滥用障碍) 之间没有发现因果关系.

关键词:

青春期青春期青春期抑郁抑郁症抑郁症抑郁症抑郁症男性青春期的时间青春期的时间心理健康心理健康

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