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Updated: May 5, 2026

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
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患有血性疾病的患者的心血管毒性:遗传预测因素研究研究

Geliya Gimatdinova1, Olesya Danilova1, Igor Davydkin1

  • 1Samara State Medical University, Samara, Russia.

Minerva cardiology and angiology
|March 28, 2025
PubMed
概括

基因查可以确定患有免疫化疗引起心血管 (CV) 毒性风险较高的患者. 特定的基因变异增加或减少这种风险,有助于患者分层并最大限度地减少不良事件.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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