Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Karyotyping01:17

Karyotyping

Overview
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Continued Nintedanib Treatment in Children and Adolescents With Fibrosing ILDs: Data From InPedILD-ON.

Pediatric pulmonology·2026
Same author

Thyroid Function with Continuous KRT: A Prospective Study.

Kidney360·2026
Same author

The effect of an experimental sleep extension manipulation on timing and duration of sedentary behavior and physical activity in habitually short-sleeping and inactive adolescents: Results from a randomized crossover trial.

Sleep health·2026
Same author

Electrical impedance tomography reveals ventilation and perfusion heterogeneity in infants with bronchopulmonary dysplasia.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Impact of a Pediatric Down Syndrome Clinic on the Identification of Celiac Disease in the Patient Population.

American journal of medical genetics. Part A·2026
Same author

Social Determinants of Health Are Associated With Length of Stay for Chronically Ventilated Children.

Pediatric pulmonology·2025

相关实验视频

Updated: May 7, 2026

EEG Mu Rhythm in Typical and Atypical Development
11:50

EEG Mu Rhythm in Typical and Atypical Development

Published on: April 10, 2014

唐氏综合征儿童的振荡计表现型

Katharine L Hamlington1,2, Emily H Cooper3, Kristine Wolter-Warmerdam4

  • 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Pediatric pulmonology
|March 28, 2025
PubMed
概括

患有唐氏综合征的儿童表现出肺功能变化,特别是下肺顺应,与常见的同时发生的肺部疾病无关. 需要进一步的研究来了解唐氏综合征中这种肺功能表型.

关键词:
一个愿望,一个愿望.肺功能 肺功能 肺功能肺动脉肺动脉是什么意思气管膜症 (tracheomalacia) 是一种三合症 21 的三合症 21.

更多相关视频

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

相关实验视频

Last Updated: May 7, 2026

EEG Mu Rhythm in Typical and Atypical Development
11:50

EEG Mu Rhythm in Typical and Atypical Development

Published on: April 10, 2014

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

科学领域:

  • 儿科肺病学 儿科肺病学
  • 遗传学和罕见疾病

背景情况:

  • 唐氏综合征与各种疾病的风险增加有关,包括肺部问题.
  • 了解唐氏综合征儿童的肺功能对于早期诊断和呼吸道并发症的管理至关重要.

研究的目的:

  • 在患有唐氏综合征的儿童中使用振荡计来评估肺功能模式.
  • 为了调查肺功能和这个人群中常见的同时发生的肺病诊断之间的关联.

主要方法:

  • 一项涉及50名患有唐氏综合征的4-18岁儿童的横截面研究.
  • 在服用阿尔布特罗尔之前和之后进行了振荡计,以测量呼吸阻力 (R) 和反应能力 (X).
  • 肺部诊断 (腹,阻塞性睡眠呼吸暂停,气管,先天性心脏病) 从医疗记录中确定.

主要成果:

  • 患有唐氏综合征的儿童表现出更多的负面反应 (X),表明肺部顺应性较低,但抵抗力正常 (R).
  • 电阻的高频率依赖 (R5-19) 表明了潜在的气道异质性.
  • 阿尔布特罗尔的使用改善了肺功能,降低了R,增加了X.

结论:

  • 在50%的唐氏综合征儿童中观察到下肺顺应的表型.
  • 这种肺功能模式与经过测试的同时出现的肺病诊断没有关联.
  • 需要进一步的研究来阐明这种肺表型与唐氏综合征之间的关系.