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Updated: Jun 19, 2026

Introducing a Gene Knockout Directly Into the Amastigote Stage of Trypanosoma cruzi Using the CRISPR/Cas9 System
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Introducing a Gene Knockout Directly Into the Amastigote Stage of Trypanosoma cruzi Using the CRISPR/Cas9 System

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关于gp82结合的原子洞察:微秒,百万个原子探索Trypanosoma cruzi的宿主细胞入侵

Raissa S L Rosa1,2,3, Manuela Leal da Silva3,4, Rafael C Bernardi1,2

  • 1Department of Physics, Auburn University, Auburn, Alabama 36849, United States.

Biochemistry
|March 28, 2025
PubMed
概括

这项研究揭示了Trypanosoma cruzi和人类细胞之间的关键分子相互作用,确定了打击查加斯病的新目标. 这项研究提供了寄生虫入侵的详细计算模型,对于开发新疗法至关重要.

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相关概念视频

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...