化学免疫治疗后的二线高级或转移性非小细胞肺癌治疗:一项回顾性研究
Lyudmila Bazhenova1, Beilei Cai2, Danielle Gentile3
1University of California San Diego Moores Cancer Center, Gilman Dr, La Jolla, CA, USA.
Future oncology (London, England)
|March 28, 2025
概括
晚期非小细胞肺癌 (aNSCLC) 的二线免疫疗法 (IO) 与非IO治疗相比显示出更好的结果. 在第一线和第二线设置中,顺序性IO治疗表明了有利的现实世界无进展生存率和整体生存率.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫疗法 (IO) 在先进非小细胞肺癌 (aNSCLC) 的第一线 (1L) 治疗中越来越多地使用,因此需要了解随后的第二线 (2L) 治疗策略.
- 这项研究侧重于患有EGFR/ALK野生型aNSCLC的患者,这是1L治疗模式已经发展的患者群体.
研究的目的:
- 描述2L治疗模式,并评估aNSCLC患者的治疗结果.
- 为了比较2LIO与非IO疗法的疗效.
- 在接受IO在1L和2L设置中接受IO的患者中评估IO重新挑战的结果.
主要方法:
- 在2016-2019年期间接受1L治疗并随后开始2L治疗的IIIB-IV期EGFR/ALK野生型aNSCLC患者的回顾性分析.
- 数据收集包括治疗方案 (2L IO,2L non-IO,1L/2L IO重新挑战) 和患者结果,截至2020年11月.
- 关键的结果指标包括整体反应率 (ORR),现实世界无进展生存率 (rwPFS) 和整体生存率 (OS).
主要成果:
- 共有194名患者开始2L治疗;93人接受IO,101人接受非IO治疗.
- 接受2LIO治疗的患者与接受非IO治疗的患者相比,中位数rwPFS (8.4vs5.1个月,p=0.0006) 和中位数OS (13.5vs7.7个月,p=0.0021) 显著较长.
- 在IO重新挑战队列 (n=12) 中,在35.0个月的中位数随访期间没有死亡,这表明了有利的结果.
结论:
- 在aNSCLC中二线IO治疗产生了与临床试验数据一致的结果.
- 在第一和第二行设置中,IO的顺序使用似乎与有利的rwPFS和OS有关.
- 对aNSCLC的顺序IO策略进行进一步的研究是有必要的,以优化治疗范式.
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