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慢性病管理的最新情况:系统性审查
Amina Ammar1,2, Stephanie B Edwin2, Rachel Whitney3
1Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, Michigan, USA.
Pharmacotherapy
|March 28, 2025
概括
新兴的慢性病 (CKD) 治疗方法显示出有前途. -葡萄糖共运输体2抑制剂 (SGLT2i) 现在是CKD的第一线治疗方法,其他药物根据患者的需要被考虑.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 慢性病 (CKD) 构成了全球相当大的健康负担.
- 目前的CKD治疗主要依赖于氨酸-血管增生素系统抑制剂 (RASi).
- 需要新的治疗策略来改善CKD的治疗结果.
研究的目的:
- 系统地审查新兴CKD疗法的疗效和安全性.
- 为了评估-葡萄糖共运输体2抑制剂 (SGLT2i),类似葡萄糖-1受体激动剂 (GLP-1RA),芬,萨库比特里尔/瓦尔萨坦和结合剂.
- 评估用于CKD管理的传统RASi之外的证据.
主要方法:
- 在PubMed,Scopus,CINAHL Complete和Web of Science核心收藏中进行系统的文献搜索.
- 包括成年CKD患者的实验和观察研究.
- 使用Cochrane RoB 2和ROBINS-I工具进行偏差风险评估.
主要成果:
- SGLT2 抑制剂在减缓CKD进展方面表现出一致的,显著的益处,使其成为RASi.i.旁边的一线治疗.
- GLP-1受体激动剂,芬和萨库比特里尔/瓦尔萨坦显示出潜力,它们的使用以患者的并发症为指导.
- 结合剂可能会促进RASi治疗的延长使用.
结论:
- SGLT2 抑制剂是现代CKD管理的基石.
- 结合新药的个性化治疗方法对于优化CKD护理至关重要.
- 进一步的研究应该集中在这些新兴疗法的比较有效性和长期安全性上.
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