在越南儿童中使用模型信息精确剂量的万科米辛:使用2个贝叶斯程序创新的中点度监测
Ba Hai Le1, Chi Kien Phung1, Olivia Yip2
1Department of Clinical Pharmacy, Hanoi University of Pharmacy, Hanoi, Vietnam.
Therapeutic drug monitoring
|March 28, 2025
概括
中点米素度监测准确评估儿科患者,为标准的2样本方法提供了方便的替代方案. 一个开源软件,Shiny,为临床使用提供了一个可行的贝叶斯模型信息精确剂量工具.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科医学 儿科医学
- 计算生物学 计算生物学
背景情况:
- 贝叶斯曲线下的面积 (AUC) 引导的万科米辛剂量为2个样本 (2S) 是为儿科患者推的.
- 基于模型的精确剂量 (MIPD) 的临床实施在低至中等收入国家是有限的,因为软件成本很高.
- 本研究比较了中点和2S抽样策略,以确定万科米辛剂量的准确性,并评估了MIPD的开源软件.
研究的目的:
- 为了比较中点的准确性和精确性与指导方针推的2样 (2S) 范科米辛剂量策略在儿科患者使用贝叶斯分析.
- 评价一个开源软件包 (Shiny) 的临床实用性,用于贝叶斯的MIPD的儿童.
- 将Shiny的性能与商业软件 (PrecisePK) 的性能进行比较.
主要方法:
- 在2家儿科医院进行了回顾性队列研究 (2022年4月至2023年4月).
- 招募了3个月至16岁的患者,他们接受了至少2个测量度 (Cmax,Cmid,Ctrough) 的万科米辛.
- 使用贝叶斯分析计算药理学参数的准确性和精度.
主要成果:
- 分析了80名儿科患者,他们的度为226个.
- 与2S方法相比,贝叶斯衍生AUC24的中点采样显示出高准确度 (5.02%) 和精度 (6.45%).
- 开源软件Shiny的准确性 (-5.58%) 和精度 (6.09%) 与PrecisePK在AUC24估计中的精度相似.
结论:
- 监测中点万科米辛度是住院儿科患者的一种方便而准确的方法.
- 开源的Shiny软件是一种可行的贝叶斯式MIPD工具,用于儿童的万科米辛剂量和监测,特别是在资源有限的环境中,如越南.
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