喷雾干燥工程的CS/HA-bilayer微针可使序列药物释放用于伤口愈合
Haowen Zhong1,2,3,4, Zongyou Chen1,2,3,4, Jiahao Huang1,2,3,4
1School of Electro-mechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, China. zhishanyuan@gdut.edu.cn.
Journal of materials chemistry. B
|March 28, 2025
概括
一种新的微针贴片可以分阶段提供药物,以加速慢性伤口愈合. 这种双相系统结合了抗菌和再生疗法,显著改善了小鼠的治愈结果.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 慢性伤口是一个重大的全球健康挑战,因为高发病率和死亡率.
- 有效的慢性伤口愈合需要逐步提供抗微生物和再生剂.
- 现有的治疗方法往往在控制药物释放方面扎,以获得最佳的治疗结果.
研究的目的:
- 开发一种带有双相药物释放系统的微针 (MN) 贴片,用于增强慢性伤口愈合.
- 将抗菌和再生功能整合到一个单一的本地化输送系统中.
- 调查分阶段药物输送在促进伤口关闭和组织再生方面的有效性.
主要方法:
- 使用溶剂造和喷雾技术制造双层MN贴片.
- 使用铜/PDMS模具,以防止在干燥过程中酸盐变形.
- 装载有氨酸 (HA) 涂层的多西环素 (DOX) 和奇托 (CS) 核心与血管内皮生长因子 (VEGF).
主要成果:
- 实验室研究表明,涂层药物 (DOX) 的快速释放 (10小时内98.8%) 和核心药物 (VEGF) 的持续释放 (长达70小时).
- 在C57小鼠的体内研究显示,在CS/HA-bilayer MNs治疗后的第九天,伤口几乎完全愈合.
- 组织学分析显示,治疗伤口中的炎症减少,上皮再生增加,原沉积增强.
结论:
- 开发的CS/HA-bilayer MN贴片有效地实现了抗菌和再生药物的分阶段输送.
- 这种综合方法通过控制感染和促进组织修复,显著加速慢性伤口愈合.
- 在先进的伤口护理中,MN贴片显示出有前途的临床应用潜力.
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