在无脊椎动物中发现和功能性描述一种bombesin类型的神经信号系统
Weiling Huang1, Xingxing Zhong1, Cleidiane G Zampronio2
1Centre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
概括
研究人员在海星中发现了一种bombesin (BN) 类型的神经系统,揭示了它在调节养行为中的古老作用,并将已知的BN信号的进化历史延伸到皮动物和带动物的共同祖先.
科学领域:
- * 进化生物学 进化生物学
- * 神经内分泌学 * 神经内分泌学
- * * 海洋生物学 海洋生物学
背景情况:
- *神经信号调节动物的重要生理和行为过程.
- * 脊椎动物神经的进化起源,如bombesin (BN),仍然是部分未知的,特别是在非带状细胞系.
- *与BN相关的 (例如,胃素释放,neuromedin B) 在动物中已知,但它们在非动物中的存在尚未得到证实.
研究的目的:
- * 调查皮动物中BN型神经信号的存在和功能.
- * 确定BN型神经的进化史.
- * 描述BN型神经在海星生理和行为中的作用.
主要方法:
- * 在皮物种中生物信息识别BN型前体蛋白.
- *质谱测量以确定海星神经 (ArBN) 的成熟结构.
- *对ArBN受体的实验鉴定,ArBN受体是一种与G蛋白结合的受体.
- *mRNA在现场杂交和免疫组织化学测绘ArBN前体分布.
- *功能性测试,以评估ArBN对海星胃和养行为的影响.
主要成果:
- * 在海星Asterias rubens中发现和描述BN型神经信号系统.
- *确定ArBN前体蛋白和成熟的ArBN.
- * 在中枢神经系统,消化系统和运动器官中定位ArBN前体表达.
- *证明ArBN诱导胃收缩/收缩,并抑制食行为.
- *鉴定了一种脊椎动物GRP/NMB型受体同类物作为ArBN受体.
结论:
- * BN型神经信号传递的进化历史可以追溯到皮动物和皮动物的双体共同祖先.
- *BN型神经在调节养行为方面起着古老的作用.
- * 这项研究确立了皮动物作为理解神经系统深层进化起源的关键模型.
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