成人白血病的诊断挑战:来自卡塔尔 (2016-2021) 单中心回顾性研究的见解
Hesham A B Aboelkhir1, Yousra El Alaoui1, Regina Padmanabhan1
1Division of Engineering Management and Decision Sciences, College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.
Cancer control : journal of the Moffitt Cancer Center
|March 28, 2025
概括
诊断白血病的延迟,包括急性髓性白血病 (AML) 等,是常见的. 诸如转诊类型和患者并发症等因素显著影响及时诊断,需要改进过程.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 及时诊断白血病对于有效的血液癌症治疗至关重要.
- 导致白血病诊断延迟的因素尚不清楚.
- 这项研究解决了有关迅速检测白血病的障碍的知识差距.
研究的目的:
- 确定阻碍及时诊断白血病的障碍.
- 分析与急性髓性白血病 (AML),慢性髓性白血病 (CML),急性淋巴细胞白血病 (ALL) 和慢性淋巴细胞白血病 (CLL) 的诊断延迟相关的因素.
- 调查转诊类型,并发症和症状对诊断时间表的影响.
主要方法:
- 卡塔尔592名白血病患者的队列分析 (2016-2021年).
- 分析了诊断延迟 (n=423),风险分层 (n=437) 和白血病阶段 (n=282) 的子组.
- 用于评估与延迟诊断的关联的单变基方位独立性测试.
主要成果:
- 观察到白血病病例的增加趋势.
- 32%的患者被诊断为高风险人群.
- 45%的患者经历了诊断延迟,平均延迟时间为44天.
结论:
- 在研究群体中发现白血病诊断的显著延迟.
- 患者转诊类型,并发症和症状等因素与诊断延迟有显著的相关性.
- 对患者,初级保健,转诊,系统和医生因素的进一步调查对于改善血液癌症的诊断和转诊过程至关重要.
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