在越南肝硬化门诊患者晚间小吃中蛋白质和BCAA之间的有效性比较:一项随机临床试验
Trang Thu Nguyen1, Linh Thuy Nguyen2, Shigeru Yamamoto3
1Nutrition and Food Culture Research Center, Jumonji University, Saitama, Japan. trangnn27@gmail.com.
Journal of gastrointestinal and liver diseases : JGLD
|March 28, 2025
概括
在肝硬化患者中,蛋白质零食显著改善了白蛋白水平和肝酶. 分链氨基酸 (BCAA) 零食的效果较低,这表明蛋白质是改善营养状况的更好的饮食选择.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床营养学 临床营养学
- 饮食干预 饮食干预
背景情况:
- 晚些时候的零食对肝硬化患者有好处,但最佳的营养成分仍然不清楚.
- 这项研究直接比较了蛋白质零食与分支链氨基酸 (BCAA) 零食.
研究的目的:
- 为了比较蛋白质零食与BCAA零食在改善肝硬化门诊患者的生物化学参数和营养状况方面的疗效.
- 在肝硬化管理中确定晚间零食的最佳营养成分.
主要方法:
- 一项为期3周的随机临床试验,涉及32名越南肝硬化门诊患者.
- 参与者被分为两组:蛋白质 (n=16) 和BCAA (n=16).
- 两组人都食用了提供270-300千卡路里,50克碳水化合物,<5克脂质和13克蛋白质 (8克蛋白质粉与4克蛋白质粉+4克BCAA粉) 的零食. 血清生化标志物,人体测量和生活质量得分在干预前后被评估.
主要成果:
- 蛋白质组的白蛋白水平显著增加 (p<0.01),但BCAA组没有.
- 在蛋白质组 (p<0.01) 中,氨酸胺转移酶 (ALT) 水平显著下降 (p<0.01).
- 蛋白质组的手握强度增加 (p=0.012),而BCAA组的增加并不显著 (p=0.237). 总体而言,慢性肝病问卷分数在两组中都有所改善.
结论:
- 蛋白质零食对于改善白蛋白,肝酶和补偿性肝硬化门诊患者的营养状况是有效的.
- 由于成本,可用性和口味方面的考虑,BCAA零食可能对这种患者群体不必要.
- 食蛋白质补充剂是治疗肝硬化的一个有价值的干预措施.
相关概念视频
Hepatic Drug Clearance: Effect of Protein Binding
728
Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
728
Bioavailability Study Design: Absolute Versus Relative Bioavailability
658
Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
658
Bioavailability Study Design: Healthy Subjects Versus Patients
252
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
252
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
274
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
274


