神经外科手术的核心结果:为坐骨髓损伤和神经病变评估制定一个核心结果集
Thomas J Wilson1, Zarina S Ali2, Gavin A Davis3
11Department of Neurosurgery, Stanford University, Stanford, California.
Journal of neurosurgery
|March 28, 2025
概括
为了在坐骨神经研究中标准化数据收集,开发了一套新的坐骨神经损伤和神经病变评估的核心结果集 (COS-SINE). 该套件确保了跨研究的一致报告和数据可比性.
科学领域:
- 神经外科 神经外科
- 临床试验方法论 临床试验方法论
- 结果测量 结果测量
背景情况:
- 核心成果集 (COSs) 对于跨研究数据的标准化,增强数据合成和可比性至关重要.
- 为了在这个领域进行一致的研究,开发一个针对坐骨神经损伤和神经病变评估的特定的COS是必不可少的.
研究的目的:
- 使用修改后的Delphi过程,开发一个用于评估坐骨髓损伤和神经病变的核心结果集 (COS-SINE).
- 建立标准化结果措施,定义和评估时间点,用于坐骨神经损伤研究.
主要方法:
- 采用了五个阶段的方法,包括联盟开发,文献审查和多个Delphi调查.
- 通过调查和最后一次会议达成共识,坚持核心成果 - 制定发展标准的建议.
- 这项研究涉及来自13个国家的23名神经外科参与者.
主要成果:
- 最终完成的COS-SINE包括36个数据点,涉及人口统计,诊断,患者报告的结果,运动/感官结果和并发症.
- 建立了标准化的仪器,测试方法和定义.
- 商定了至少24个月的随访,在手术前和手术后3,6,12,24和36个月的最佳评估点.
结论:
- 神经外科的核心成果 (COINS) 联盟成功开发了一个共识COS-SINE,定义了实施方法和评估时间表.
- COS-SINE为未来的神经外科研究提供了关于坐骨神经损伤和神经病变的最低数据集.
- 预计实施这一COS将改善报告的一致性,数据综合,可比性,并减少结果报告偏差.
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