SARS-CoV-2 omicron 变种感染对儿童发作的影响:大型多中心研究

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Juhyun Kong¹, Sooyoung Lyu¹, Sang Ook Nam¹

¹Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, South Korea; Pusan National University School of Medicine, Yangsan, South Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, South Korea.

Brain & development

|March 28, 2025

概括

COVID-19的Omicron变种显著增加了儿科发作,22%的病例发生在Omicron后,而之前的0.3%. 发作通常与COVID-19感染有关,但也注意到了和MIS-C等其他诊断.

科学领域:

神经学神经学
传染性疾病传染性疾病
儿科儿科儿科

背景情况:

报道称,COVID-19大流行,特别是Omicron变种的激增,已经与儿科发作的增加有关.
有限的文献存在,比较不同流行病阶段的发病率.

研究的目的:

调查COVID-19 Omicron变种传播前后儿科患者中发作的发生率和临床特征.
为了比较在Omicron前期和Omicron后期之间的发作发生率和特征.

主要方法:

从2020年到2022年,韩国七家医院对被诊断患有COVID-19的儿科患者进行了回顾性分析.
根据在韩国出现的Omicron变种 (2022年1月1日) 的情况,患者被分为Omicron前和Omicron后的组.
两组的发病率和临床数据进行了比较.

主要成果:

总共分析了1608名儿科患者.
后Omicron组 (n=1293) 与前Omicron组 (n=315,0.3%) 相比,COVID-19相关的发作 (22%) 的发生率显著更高.
在Omicron后的发作中,常见的诊断包括COVID-19感染 (83.6%), (13.6%),以及较少的,神经炎症性疾病,MIS-C和低血发作.

结论:

SARS-CoV-2 Omicron 变种与明显高的发作发病率有关,作为儿童呈现的症状.
虽然许多发作直接与Omicron感染有关,但也观察到其他神经疾病,如,MIS-C,神经炎症疾病和低血症.

关键词:

在 COVID19 疫情下,这就是Omicron.这就是SARS-CoV-2病毒.发作发作发作

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