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Updated: Jul 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

针对RAS-RAF相互作用的接抑制剂的设计,合成和抗瘤活性

Dan Han1, Zhou Yu2, Kai Zhang2

  • 1School of Health Sciences and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, PR China; Department of Burn Plastic Surgery, The Second Affiliated Hospital of Second Military Medical University, Shanghai, 200003, PR China.

European journal of medicinal chemistry
|March 28, 2025
PubMed
概括

研究人员开发了改性来向KRAS,这是癌细胞生长中的关键蛋白质. 这些新的类药物通过提高稳定性和细胞透性来改善癌症治疗的前景,提供了一种超出小分子抑制剂的新方法.

关键词:
在 AKT AKT 里面.这是一种抗瘤药物.RAS-RAF的相互作用接质类的类.

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