在二次渐进性多发性硬化症中,身体健康与结构性和功能性MRI测量之间的关联:来自运动PRO-MS研究的横截面发现
A S Gravesteijn1, A van der Kruit2, M Bet2
1Amsterdam UMC location Vrije Universiteit Amsterdam, Rehabilitation Medicine, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Neuroinfection & -inflammation, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, the Netherlands; MS Center Amsterdam, Amsterdam, the Netherlands.
Multiple sclerosis and related disorders
|March 28, 2025
概括
二次进展性多发性硬化症 (SPMS) 的身体健康与大脑MRI测量没有显著的相关性. 然而,趋势表明心肺健康可能会影响感官运动网络连接.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 康复科学 康复科学 康复科学
背景情况:
- 二次渐进性多发性硬化症 (SPMS) 的特征是神经系统的逐渐衰退.
- 了解影响SPMS中大脑结构和功能的因素对于开发有效干预措施至关重要.
研究的目的:
- 调查SPMS患者的身体健康和脑MRI指标之间的关系.
- 将SPMS患者的身体健康和MRI测量与参考数据进行比较.
主要方法:
- 评估了29名SPMS参与者的心肺呼吸能力,腿部肌肉强度和身体活动水平.
- 利用大脑MRI测量大脑体积和默认模式网络 (DMN) 和感觉运动网络 (SMN) 的静止状态功能连接 (rsFC).
- 采用了多重线性回归,并将结果与健康对照和公布的参考数据进行了比较.
主要成果:
- 与健康对照人群相比,SPMS参与者表现出较低的身体健康,脑体积减少,SMN-脑 rsFC减少.
- 在邦费罗尼校正后,身体健康参数和脑磁共振测量之间没有发现统计学意义上的关联.
- 观察到的趋势表明,更好的心肺呼吸能力和更高的SMN-大脑rsFC,以及更高的身体活动和DMN-大脑rsFC之间存在潜在联系.
结论:
- 在这个SPMS队列中,身体健康与大脑体积测量没有显著的关联.
- 新兴趋势表明,身体健康可能会影响SPMS患者的功能性大脑连接 (SMN和DMN).
- 需要进一步的研究来证实这些潜在的关联及其临床影响.
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