在乳腺癌后导航骨健康
12nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece; Royal Free Hospital NHS Trust, Medical School, UK; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Maturitas
|March 28, 2025
概括
乳腺癌的内分泌治疗可以导致骨质损失. 骨修饰剂 (BMA) 有助于预防骨折,但对于乳腺癌患者的最佳选择需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 乳腺癌是女性死亡的主要原因之一.
- 激素受体阳性乳腺癌的治疗包括手术和内分泌疗法.
- 内分泌疗法可能导致骨矿物质密度 (BMD) 降低,骨折风险增加.
研究的目的:
- 审查骨修饰剂 (BMA) 在乳腺癌患者骨健康管理中的作用.
- 评估不同BMA在预防骨损失和骨折方面的有效性.
- 讨论BMA在乳腺癌治疗中的使用现有建议和未来的研究需求.
主要方法:
- 对乳腺癌患者BMA研究的文献综述.
- 对骨折预防和对疾病复发的影响的证据分析.
- 审查BMA对绝经前和绝经后妇女的建议.
主要成果:
- 静脉注射佐莱德酸盐在绝经前妇女的骨质损失预防方面是有效的,但其对复发的影响尚不清楚.
- 德诺苏马布在绝经后妇女中显示出骨折预防的证据,但缺乏抗癌益处.
- 双酸盐可以减少脊椎骨折,但整体骨折风险的降低是不确定的. 在这个人群中,FRAX算法可能低估了风险.
结论:
- 在接受内分泌治疗的乳腺癌患者中,BMA对于管理骨健康至关重要.
- 目前的建议有利于使用克洛德罗纳酸,伊班德罗纳酸和索尔德罗尼酸来保护骨,而不是使用德诺苏马布.
- 需要进一步的研究,以根据患者个体特征确定最佳的BMA.
相关概念视频
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Nursing Ethical Principles II
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
Peripheral Artery Disease IV: Nursing Management
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease V: Postoperative Nursing Management
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...


