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怀孕初期和中期尿液中对和妊娠糖尿病的度:在PETALS队列中进行的一项嵌套病例对照研究

Alicia K Peterson¹, Yeyi Zhu¹, Juanran Feng²

¹Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, United States of America; Center for Upstream Prevention of Adiposity and Diabetes Mellitus (UPSTREAM), Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, United States of America.

The Science of the total environment

|March 28, 2025

概括

在怀孕期间常见的帕拉本暴露与妊娠期糖尿病 (GDM) 整体没有联系. 然而,亚洲/太平洋岛屿妇女在甲基,乙基和基暴露时,GDM几率增加.

科学领域:

环境健康环境健康
生殖健康生殖健康
内分泌学在内分泌学.

背景情况:

烯是广泛使用的防腐剂,具有已知的内分泌干扰特性.
在怀孕期间对葡萄糖代谢和妊娠期糖尿病 (GDM) 的帕拉本暴露的影响仍然不清楚.
内分泌干扰化学物质在孕产妇健康方面越来越令人担忧.

研究的目的:

调查怀孕早期和中期尿液中类度与发展GDM的风险之间的联系.
探索种族/种族,特别是亚洲/太平洋岛民 (A/PI) 身份对-GDM关系的潜在影响修改.

主要方法:

一个匹配的病例控制研究嵌入在PETALS纵向怀孕队列中.
用质谱测量测量了尿液中对的度 (甲基对,乙基对,基对,丁基对).
条件后勤回归模型评估了关联,对共变量进行调整,并检查了与A/PI种族/民族的相互作用.

主要成果:

总体而言,对的暴露与GDM风险没有显著关联.
在A/PI参与者中,更高的甲基合剂度与增加的GDM概率有关.
在怀孕中期增加的乙基和基暴露也显示出更高的GDM几率,特别是在A/PI个体中,具有显著的相互作用效应.

结论:

虽然对的总体暴露与GDM没有相关性,但A/PI种族/种族的显著相互作用表明潜在的风险增加.
特定的帕拉本 (甲基帕拉本,乙基帕拉本,基帕拉本) 可能与A/PI孕妇的GDM几率增加有关.
需要进一步的研究来阐明这些种族特异性关联以及 parabens 在怀孕代谢健康中的作用.

关键词:

欧洲发展中心 (EDCs)内分泌干扰化学物质可以破坏内分泌.在GDM中,GDM是GDM.孕期糖尿病孕期糖尿病帕拉本类药物可以怀孕怀孕怀孕怀孕

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