相关实验视频

Updated: Jul 19, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

针对性的CDK9降解会严重破坏MYC监管的网络

Mohammed A Toure1, Keisuke Motoyama2, Yichen Xiang1

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 04142, USA.

Cell chemical biology
|March 28, 2025
PubMed
概括

针对性降解循环素依赖性激酶9 (CDK9) 比抑制更有效,用于癌症治疗. 降解克服了反机制,限制了CDK9抑制剂的有效性,特别是在MYC调节方面.

关键词:
在CDK9中,CDK9是CDK9.我的世界 MYC这就是PROTAC.癌症治疗疗法 癌症治疗降解与抑制相比降解与抑制.有针对性的降解降解目标.转录 转录 是一种转录.

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