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工作记忆训练对认知灵活性,树突脊柱密度和雌性小鼠长期增强潜力的影响

Vasiliki Stavroulaki¹, Lida-Evmorfia Vagiaki², Orestis Nikolidakis³

¹Dept of Biology, University of Crete, Greece; Laboratory of Neuropsychology, Department of Psychology, School of Social Sciences, University of Crete, Rethymno, Crete 74100, Greece; University of Crete Research Center for the Humanities, the Social and Education Sciences (UCRC), University of Crete, Rethymno, Crete 74100, Greece.

Behavioural brain research

|March 28, 2025

概括

在雌性小鼠中,工作记忆训练 (WMT) 增强了海马突触可塑性和脊柱密度,但没有认知灵活性或前额叶皮质可塑性. 这些发现揭示了WMT的性别特异性神经生物学影响.

科学领域:

神经科学是一个神经科学.
认知科学认知科学

背景情况:

工作记忆 (WM) 对于目标导向行为至关重要,涉及前额叶皮质 (PFC) 和海马体 (HPC).
工作记忆训练 (WMT) 可以改善认知功能,但它的神经生物学基础,尤其是女性,仍然不清楚.
之前的研究表明,WMT增强了雄性小鼠的PFC和HPC中的突触和结构可塑性.

研究的目的:

研究WMT对成年雌性小鼠认知灵活性和突触可塑性的影响.
为了比较PFC和HPC在适应性WMT后的神经生物学变化与非适应性任务和没有训练.

主要方法:

成年雌性小鼠被分为原始的,非适应性T迷宫交替和适应性延迟交替任务 (WMT) 组.
用注意力设置转移 (AST) 任务来评估认知灵活性.
状脊柱密度通过戈尔吉-考克斯染色分析.
在PFC和HPC片中使用现场刺激后突触潜能 (fEPSP) 记录,特别是长期潜能 (LTP) 记录来测量突触可塑性.

主要成果:

两组之间没有观察到AST表现的显著差异,尽管适应性WMT组显示选择延迟减少.
与原始小鼠相比,适应性WMT组的HPC增加了状脊柱密度,但与原始小鼠相比,适应性WMT组的PFC没有增加.
在适应性WMT组中,HPC的长期增强 (LTP) 与非适应性和原始组相比显著增强.
在PFC中,泰坦尼克诱导的LTP在各组之间没有差异.

结论:

适应性WMT在雌性小鼠中增强海马突触可塑性和树突脊柱密度.
通过AST任务测量认知灵活性,在这个雌性小鼠队列中,WMT并没有显著改善WMT.
该研究强调了WMT对认知功能和可塑性的神经生物学影响的相似性和性别特异性.

关键词:

注意力设置转移任务的任务延迟交替任务任务的延迟在海马体内,海马体前额叶皮层前额叶皮层.

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