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在刺激性肠综合征的老鼠模型中,伊丽素可以预防内脏过敏和结肠过性
Tsukasa Nozu1, Saori Miyagishi2, Masatomo Ishioh2
1Department of Regional Medicine and Education, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Center for Medical Education, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.
素,一个myokine,有效地减少内脏过敏和肠道屏障功能障碍在刺激性肠综合征 (IBS) 鼠标模型. 它通过AMP激活蛋白激酶 (AMPK),氧化 (NO) 和多巴胺D2信号通路起作用.
科学领域:
- 胃肠病学 胃肠病学
- 神经内分泌学神经内分泌学
- 分子医学是分子医学.
背景情况:
- 刺激性肠综合征 (IBS) 的病理生理学包括内脏过敏,肠道屏障功能受损和轻度炎症.
- 皮质otropin释放因子 (CRF) 和类似收费受体4 (TLR4) 信号通路相互作用,促进胃肠道炎症.
- 素,一种肌素,通过抑制TLR4信号传递,显示出抗炎性质,提供潜在的治疗益处.
研究的目的:
- 调查伊丽素在改善肠部过敏和肠道屏障功能障碍中的潜力,在IBS的老鼠模型中.
- 探索潜在的分子机制,包括AMP激活蛋白激酶 (AMPK),氧化 (NO) 和神经递质信号通路,涉及到素的作用.
主要方法:
- 利用脂聚糖 (LPS) 和CRF诱导雄性斯普拉格-道利大鼠的IBS类症状.
- 通过电生理学监测在结肠气球膨胀期间腹肌收缩的评估内脏疼痛值.
- 使用埃文斯蓝色染料吸收量化结肠透性,并评估了虹膜素和特定途径抑制剂的作用.
主要成果:
- 内皮质里素的剂量取决于剂量,可以预防LPS诱导的内脏过敏和结肠透性.
- 在IBS模型中,Irisin还改善了CRF诱导的胃肠道变化.
- 素的有益作用被AMPK的抑制剂,NO合成,多巴胺D2受体,胆固醇通路和素1受体逆转.
结论:
- 虹膜素通过改善内脏感觉和结肠屏障功能来证明IBS的显著治疗潜力.
- 这些改善通过涉及AMPK,NO,多巴胺D2,胆固醇和素系统的复杂信号通路进行介导.
- 虹膜代表了一种有前途的新型治疗候选药物,用于控制IBS症状.
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