在儿科患者的运动测试期间心室心律失常,在第一次呈现时患有心律失常性心肌病,并且有不同的心室干扰
Marianna Cicenia1, Michele Lioncino1, Nicoletta Cantarutti1
1Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart).
Heart rhythm
|March 28, 2025
概括
在儿科心律失常性心肌病 (ACM) 中的运动测试显示了可变心室节律失常 (VAs),在运动期间有一些抑制,但在运动高峰和恢复期间的患病率增加. 基线PVC和恢复VA与ACM存在相关.
科学领域:
- 心脏病学 心脏病学
- 儿科电子生理学 儿科电子生理学
- 心血管遗传学 心血管遗传学
背景情况:
- 心室心律不整 (Vas) 是儿科心律不整心肌病 (ACM) 的主要表现.
- 在早期儿科ACM中,运动测试 (ET) 的心律失常潜力尚不清楚.
研究的目的:
- 在患有早期心律失常心肌病的儿科患者中进行运动测试的节律失常性特征.
- 为了比较儿科ACM患者的运动诱导的心律失常症与对照组.
主要方法:
- 招募的儿科患者被诊断为确定的ACM.
- 分析了ET在初始呈现和治疗后的结果.
- 将ACM患者与经历过过早心室综合体 (PVCs) 的对照组进行比较,而没有结构性心脏病.
主要成果:
- 在基线时,80%的ACM患者有VA (3个不持续的VT,17个孤立的PVC).
- 在运动的高峰期,40%的ACM患者和10%的对照人群表现为VA;在康复期间,68%的ACM患者和8%的对照人群表现为VA.
- 在基线的左捆分支块-上轴PVC和恢复期间的VA与ACM有显著的关联 (P = .0038,P < .0001).
- 在康复期间多态和非持续性心室动脉冲动在双心室ACM (BIV-ACM) (P = .03) 中更频繁.
结论:
- 儿科ACM的运动测试显示了可变的VA行为,包括运动诱导的抑制.
- 在峰值运动和恢复期间的VA,以及特定的基线PVC特征,是ACM的指标.
- 虽然VA形态和ET反应不能预测ACM表型,但在BIV-ACM中,复苏期间的多态和非持续的VT更为常见.
相关概念视频
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