慢性盆腔疼痛和肉毒毒素的作用
Barbara Illowsky Karp1, Pamela Stratton1
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
概括
毒素显示出治疗男性和女性慢性盆腔疼痛的潜力. 虽然针对女性的研究结果各不相同,但针对男性的新兴研究表明,这种使人衰弱的疾病的结果很有希望.
科学领域:
- 研究毒素在泌尿和妇科的应用.
- 专注于疼痛管理和慢性盆腔疼痛综合征的治疗.
背景情况:
- 慢性盆腔疼痛是一种广泛的疾病,导致严重的痛苦和残疾.
- 目前治疗男性和女性慢性盆腔疼痛的方法存在局限性.
- 毒素是一种新兴的治疗疼痛管理的选择.
研究的目的:
- 审查当前关于肉毒素用于治疗两性慢性盆腔疼痛的证据.
- 讨论在盆地肌肉中注射肉毒素的疗效和安全性.
- 探索肉毒毒素对男性慢性前列腺炎/慢性盆腔疼痛综合征的潜力.
主要方法:
- 关于治疗慢性骨盆疼痛的肉毒素现有无控研究和随机对照试验的综述.
- 对女性的盆地肌肉 (例如,levator ani,obturator internus) 中的注射部位的分析.
- 对男性慢性骨盆疼痛的有限临床试验的检查,注意到不同的注射部位.
主要成果:
- 在女性身上进行的许多不受控制的研究表明,毒素对慢性盆腔疼痛有好处.
- 已发表的女性随机对照试验已经产生了模两可或不确定的结果.
- 在男性慢性骨盆疼痛中进行的一些临床试验显示出有希望的结果,尽管方法不同.
结论:
- 毒素是男性和女性慢性盆腔疼痛的潜在治疗途径.
- 需要进一步进行高质量的研究,特别是随机对照试验,以确认有效性,特别是在女性中.
- 在男性慢性骨盆疼痛中使用肉毒素需要继续调查.
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