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Updated: May 20, 2025

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在CSF1R信号,单细胞-巨分化的关系,和易受炎症性肠病的敏感性之间的关系

David A Hume1, Kim M Summers1, Claire O'Brien2

  • 1Mater Research Institute, University of Queensland, Woolloongabba, Brisbane, Australia.

Cellular and molecular gastroenterology and hepatology
|March 28, 2025
PubMed
概括

与炎症性肠病 (IBD) 风险相关的遗传变异可能会损害单细胞适应. 失调ETS2和CSF1/CSF1R信号破坏了抗炎性肠道巨细胞的形成,可能会加剧IBD.

关键词:
殖民地刺激因子-1这是ETS2的第二个版本.全基因组关联研究研究.炎症性肠道疾病 炎症性肠病一个单细胞单细胞.

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