多层网络中的动态模块失调是第一发精神分裂症认知和临床缺陷的基础
Xinyi Hu1, Xiangyun Long2, Jiaxin Wu1
1Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
第一发精神分裂症患者表现出大脑网络动态的改变,在关键的大脑网络中具有更高的模块化和增加节点灵活性. 这些变化与认知缺陷和负面症状相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 精神分裂症与大脑功能网络异常有关,影响认知和功能.
- 虽然已知静态网络中断,但精神分裂症中的动态网络变化仍然不清楚.
研究的目的:
- 研究第一发精神分裂症 (FES) 患者的动态功能连接和模块化.
- 探索动态网络灵活性,认知功能和FES的临床症状之间的关系.
主要方法:
- 82名FES患者和55名健康对照 (HC) 的休息状态fMRI数据.
- 动态功能连接矩阵和多层网络分析以实现动态模块化.
- 结节灵活性,认知测试和临床症状尺度之间的相关性分析.
主要成果:
- 与HC相比,FES患者表现出明显更高的多层模块化.
- 在FES患者的默认模式,前端-双侧,突出和视觉网络中观察到高节点灵活性.
- 异常区域中的节点灵活性与FES的认知表现和负面症状有显著的相关性.
结论:
- 精神分裂症的特征是异常的大脑网络动态和模块化组织.
- 变化的动态网络灵活性可能是FES认知障碍和功能缺陷的基础.
- 研究结果表明,大脑网络动态中的病理不平衡有助于精神分裂症的病理生理学.
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