急性压力通过依赖微生物群的机制,增强雄性小鼠的突触可塑性
Cristina Rosell-Cardona1, Michael K Collins2, Kenneth J O'Riordan1
1APC Microbiome Ireland, University College Cork, Cork, Ireland.
Neuropharmacology
|March 28, 2025
概括
肠道微生物群对于应激来增强突触可塑性至关重要. 微生物代谢物酸盐可以恢复海马体中压力诱导的可塑性变化,即使没有微生物群.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 生理学 生理学 生理学
背景情况:
- 急性压力会影响突触可塑性,但其与肠道微生物群的相互作用是未知的.
- 肠道微生物群影响海马的可塑性,但其在与压力相关的可塑性中的作用尚不清楚.
研究的目的:
- 研究肠道微生物群,急性压力和海马突触可塑性之间的相互作用.
- 为了确定微生物代谢物丁酸盐是否可以逆转压力诱导的可塑性变化.
主要方法:
- 在成年雄性小鼠身上进行了电生理学和分子实验.
- 小鼠接受了抗生素治疗,以耗尽肠道微生物群,并遭受了急性压力.
- 河马切片被用酸盐处理,以评估其影响.
主要成果:
- 肠道微生物群对于压力诱导的短期和长期潜能增强至关重要.
- 丁酸盐恢复了微生物群枯竭的小鼠的压力诱导的潜能,并独立地增强了长期潜能.
- 观察到海马突触可塑性标记物的变化.
结论:
- 肠道微生物群在调解急性压力对海马突触可塑性的影响方面发挥着至关重要的作用.
- 肠道衍生代谢物,如丁酸盐,是调节应激反应和突触功能的关键.
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