非P42表位的MOG抗体与儿科MOGAD复发的风险更高有关
Aseel El Hajj1, Anne Ruiz2, Antoine Gavoille3,4
1Forgetting Team, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, Université Claude Bernard Lyon 1, Lyon, France.
Journal of neurology, neurosurgery, and psychiatry
|March 28, 2025
概括
结合突变的髓寡干细胞糖蛋白变体 (非P42) 预测患有髓寡干细胞糖蛋白抗体相关疾病 (MOGAD) 的儿童的复发率更高. 这一发现确定了MOGAD预后的潜在生物标志物.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 需要生物标志物来预测髓寡干细胞蛋白抗体相关疾病 (MOGAD) 的临床过程.
- 结合一种突变的MOG蛋白变体 (MOG-P42S;非P42) 与成人MOGAD患者复发风险增加有关.
研究的目的:
- 评估儿童MOGAD患者与非P42MOG变体结合的频率.
- 研究非P42 MOG结合与儿科MOGAD临床概况/病程之间的关联.
主要方法:
- 包括来自五个中心的MOG-Ab血清阳性样本的儿童.
- 用本地MOG (MOG-FL) 和突变MOG-P42S进行了基于活细胞的测试.
- 与临床数据相关的测定结果.
主要成果:
- 在81名MOG-FL阳性患者中,有40人结合了非P42的MOG变种.
- 非P42结合与早期发病年龄 (p=0.002) 和不同的表型 (p=0.001) 相关,主要是急性传播性脑筋炎.
- 非P42组显示出明显更高的复发率 (RR:2.6;p=0.03),调整为表型.
结论:
- 非P42的MOG变体是预测儿科MOGAD复发的有希望的生物标志物.
- 确定非P42结合可以帮助儿童MOGAD的风险分层和管理.
关键词:
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