大型和非常大的 (≥7厘米) 肺癌的侵略性Versus不那么侵略性的非手术治疗是否重要?
Federico Ampil1, Carlos Previgliano2, Kim Heath3
1Department of Radiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. federico.ampil@lsuhs.edu.
Anticancer research
|March 28, 2025
概括
大型和非常大的肺癌 (LVL-LC) 的非手术治疗显示出有希望的瘤回归和无进展的生存. 积极的治疗策略为LVL-LC提供了一个合理的方法,具有可接受的毒性.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 辐射疗法 辐射疗法
背景情况:
- 大型和非常大的肺癌 (LVL-LC) 很少研究非手术治疗选择.
- 描述了LVL-LC的非操作性管理,其意图明确.
研究的目的:
- 评估大型和非常大型肺癌 (LVL-LC) 的非手术治疗结果.
- 评估LVL-LC的最终和息性非手术治疗的疗效和毒性.
主要方法:
- 在2012年至2022年期间,对39名LVL-LC患者进行了非手术治疗的回顾性审查.
- 患者接受了终极治疗 (同时进行化学放射治疗) 或息治疗 (短期放射治疗与化疗,化疗或仅放射治疗).
主要成果:
- 整体瘤回归率为82%,疾病进展率为67%,平均存活时间为13个月.
- 与息治疗方法相比,最终治疗显示出瘤回归和存活率更好的结果的趋势.
- 在65%的患者中观察到低度的短暂副作用,26%的患者有肺纤维化.
结论:
- 积极的非手术治疗是LVL-LC的可行策略,促进瘤解脱和无进展的生存.
- 这种方法为患有大型和非常大型肺癌的患者提供了可接受的毒性.
- 高龄患者患有非非常大的上叶癌症可能会从终极治疗中获益,以延长存活时间.
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