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Updated: Jul 14, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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抗结核药物BTZ-043的群体药理动力学和暴露-反应关系

Simon E Koele1, Norbert Heinrich2,3,4, Veronique R De Jager5

  • 1Department of Pharmacy, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.

The Journal of antimicrobial chemotherapy
|March 28, 2025
PubMed
概括

这项研究描述了BTZ-043的药理动力学和早期暴露-反应,这是一种新的结核病治疗方法. 较高剂量显示细菌负载的下降速度更快,但暴露-反应关系仅限于最初的两天.

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