在心力衰竭的成年人中,老年人的脆弱性与保存的喷射部分:跨大陆评估
Parag Goyal1, Omar Zainul1, Yashika Sharma2
1Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
JACC. Advances
|March 28, 2025
概括
老年人的脆弱性,如虚弱性,在患有心力衰竭的老年人中很常见,心力衰竭具有保存的喷射分数 (HFpEF). 这些问题显著增加了住院和一年内死亡的风险.
科学领域:
- 老年医学 老年医学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 保持喷射分数 (HFpEF) 的心力衰竭不成比例地影响着老龄化人口.
- 老年人的脆弱性在患有HFpEF的老年人中普遍存在.
研究的目的:
- 确定患有HFpEF的患者在多个健康领域中老年人脆弱性的流行率.
- 调查这些漏洞对住院和死亡率的预后影响.
主要方法:
- 来自威尔康奈尔医学 (WCM) 和OPTIMISE HFpEF计划的连续HFpEF患者的分析.
- 评估多种疾病,多种药物,认知障碍,抑郁症状,虚弱和有限的运动能力.
- 考克斯的比例危险模型用于评估老年人脆弱性与所有原因住院和死亡率的一年复合之间的关联.
主要成果:
- 在这两组患者中,近一半的患者在所有三个健康领域都表现出老年人的脆弱性.
- 脆弱与两个队伍中主要结局的风险增加有显著的关联.
- 越来越多的健康领域受损与更高的风险相关,三个受损的领域使风险增加了近四倍.
结论:
- 在成年人中,老年人的脆弱性经常与HFpEF并存.
- 这些脆弱性独立地与更糟糕的预后有关,包括增加住院治疗和死亡率.
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