社会关系和遗传风险与脆弱性相关联
Wei-Qi Song1, Wen-Fang Zhong1, Hao-Yu Yan1
1Department of Epidemiology (WQS, WFZ, HYY, ZHL, JG, XMW, PLC, FFY, CL, HC, JHX, CM), School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
概括
糟糕的社会关系增加了老年人,特别是那些具有高遗传风险的人的虚弱风险. 持续的负面社会联系会随着时间的推移放大这种风险.
科学领域:
- 老年学是一门学科.
- 社会流行病学 社会流行病学
- 遗传学 遗传学 是一个
背景情况:
- 脆弱性是全世界老龄化人口日益关注的问题.
- 社会关系被认为是以后生活中健康结果的关键决定因素.
- 社会因素,遗传倾向和脆弱性之间的相互作用仍然不完全理解.
研究的目的:
- 检查社会关系 (活动,网络,支持) 和老年人中事件脆弱之间的关联.
- 调查社会关系的变化如何影响脆弱风险.
- 要确定通过多基因风险评分 (PRS) 量化的遗传风险是否会改变这些关联.
主要方法:
- 分析了来自中国纵向健康长寿调查的11,559名老年人的队列.
- 在三个维度中,社会关系被归类为有利或不利.
- 考克斯的比例危险模型和门德尔的随机化被用来评估脆弱性风险和因果关系.
主要成果:
- 不利的社会关系,特别是在社会活动和网络中,与脆弱性风险的增加有关.
- 具有高遗传风险的个体表现出来自不良社会关系的放大效应.
- 结合不利的社会关系和高遗传风险,显著增加了脆弱风险 (HR:1.39).
结论:
- 不利的社会关系是老年人虚弱的重要危险因素.
- 遗传易感性加剧了贫穷的社会联系对脆弱性的有害影响.
- 针对社会参与的干预措施可能对遗传风险较高的老年人特别有益.
相关概念视频
Relationship Formation
28.4K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
28.4K
Factors Affecting Illness
5.4K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.4K
Human Genetics
2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Social Relationships and Well-Being
513
The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
513
Importance of Need for Affiliation
438
The need for affiliation is a fundamental human motive that drives individuals to form and maintain interpersonal relationships. This universal drive varies in intensity among individuals due to genetic predispositions and life experiences, shaping it into a relatively stable personality trait. Social inclusion enhances emotional well-being by fulfilling the need for affiliation, whereas social exclusion leads to distress, negative emotions, and cognitive impairments.Psychological and Emotional...
438
Relationship with Other Adult Family Members and Siblings
281
Other adult family members and siblings play a crucial role in shaping children’s social and emotional development. While parents or primary caregivers are often the central figures in early attachment and socialization, other adults in a child’s life, such as grandparents, aunts, and uncles, can significantly influence developmental outcomes. These influences depend on each adult’s personality and may help compensate when a primary caregiver is emotionally distant or...
281


