根据潜在疾病的流感相关住院率,2016-17年至2019-20年:一项回顾性队列研究
Aaron M Frutos1,2, Mark W Tenforde1, Devi Sundaresan1
1Influenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, United States.
The Journal of infectious diseases
|March 28, 2025
概括
患有潜在疾病的个人面临更高的流感住院风险. 管理这些疾病和接种疫苗对于预防至关重要,特别是对于高风险群体.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 内部医学 内部医学
背景情况:
- 潜在的疾病 (UMC) 是流感相关住院的已知风险因素.
- UMC类型和数量的对这些住院率的影响需要进一步调查.
研究的目的:
- 评估流感相关住院率如何因潜在疾病的类型和数量而有所不同.
- 评估UMCs对住院率的影响,考虑到流感疫苗接种状态.
主要方法:
- 成人卫生系统成员的回顾性队列研究 (2016-2020).
- 根据出院诊断或实验室确认,估计了与流感相关的住院率.
- 调整后的利率比率 (ARR) 使用波桑回归计算,控制共变量.
- 因果调解分析探讨了疫苗接种状况的作用.
主要成果:
- 充血性心力衰竭为流感住院的最高aRR (4.2).
- 住院的风险增加了每一个额外的UMC.
- 当没有接种疫苗的介导时,UMCs对住院的影响更为明显;与没有接种疫苗的人相比,≥4个UMCs的个体的发病率高出~60%.
结论:
- 较高的UMC负担与流感相关住院率的增加显著相关.
- 流感疫苗接种在减轻住院风险方面发挥着至关重要的作用.
- 预防性医疗护理和年度疫苗接种对于高风险人群至关重要.
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